Background: Hemophagocytic lymphohistiocytosis syndrome (HLS) is an immune-mediated life-threatening disease\nconsidered as a medical emergency, with a potentially fatal multisystem inflammatory outcome. We present a\npatient that developed HLS and was able to be diagnosed efficiently with the help of an academic research institute\nof immunology.\nCase presentation: A 21 years old male Mexican with human immunodeficiency virus (HIV), late presenter; who\ndeveloped cytomegalovirus (CMV) infection and a disseminated histoplasmosis-related HLS, as part of an immune\nreconstitution inflammatory syndrome (IRIS). The patient required a long course of corticotherapy, intravenous immunoglobulin\nand massive transfusions (more than 10 units in 24 h, and a total of 83 units), besides amphotericin-B and\nganciclovir treatment. An academic research institute of immunology aided in the accurate diagnosis of HLS with the\nimplementation of tests not available within the hospital, thus improving the care provided to the patient. The patient\nrecovered, was discharged, and continue to improve.\nConclusion: The objective of this report is to highlight the importance of having multidisciplinary support, including\nbasic medical sciences groups providing specific tests.................
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